"I like keeping Gale bitchy. She has a reputation to live up to. She may have changed her hair but not much else." about her character Gale Weathers in the Scream series

"I get so bored! I had a treadmill... I gave it to my mom. I had a stairmaster... gone. I had a recumbent bike...I dont know where that is. So I hate exercise except for Pilates."

"I'm a gemini, and I get so bored so easily. I mean, I have moved six times in the last eight years."

"A lot of my humor does come from anger. It's like, you're not gonna pull one over on me-which is pretty much my motto anyways."

"I'm not a huge fan of romantic comedimes- my taste goes much more to the offbeat and dark. I'd love to sink my teeth into something like 'Fargo'"

"I only have to do three things to look halfway decent, curl my eyelashes, fill in my eyebrows and put some lipstick on."

"I have to be physically attracted to someone. But I can't just be with someone just because it's great sex. Because orgasms don't last long enough."

"Honesty is the key to a relationship. If you can fake that, you're in."

"Before he moved in, David would say 'How are we ever going to meld together, because our tastes are so different? Maybe it's because we're truly in love that we can". - on husband David Arquette

"I want people to be happy, so I think that's one of the reasons why I wanted to do the show in the first place...just to see somebody, even if it's just for the day. To see their life change for that moment when they walk into the room and are that happy. It really makes you cry. It does. I hope I don't lose this feeling." - on producing her show "Mix it Up".

"It's so much fun for us. I have a new love for the show since I've gotten into this relationship. Honestly, I was a little bored the first four years. I had some fun things to do and some good relationships, but Monica was developing and I felt like there was a lot of straight man stuff. Now we have something really fun to play -two really neurotic people trying to have a relationship. They're both afraid to commit, to get married, or take these steps. I have a really good time playing with him [Matthew Perry]. It's kind of like our relationship in real life - except we don't kiss." - about playing Monica and Chandler.

"I can definitely act even if I don't appear to have any particular style. I know I'm not a method actress, but I do believe in being physically and emotionally prepared for the role. If I have a scene where I'm supposed to be emotionally drawn out, then I'll think of the saddest thing in my life. If I have to be five pounds lighter to be the right physical type, I'll run my little tail around the block to make the weight."